Photo: Alika Jenner / Getty Images Sport / Getty Images
The Minnesota Timberwolves face the Portland Trail Blazers as 4.5-point favorites in the first game of the 2025-26 NBA season for both teams on Wednesday, October 22, 2025 at 10 p.m. ET on KUNP and FDSN.
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Listen to the game on Rip City Radio 620 Portland
Timberwolves vs. Trail Blazers Predictions for Wednesday
Our computer projections model for this contest expects a final tally of Timberwolves 115, Trail Blazers 109.
- Moneyline Pick: Timberwolves (-195)
- Total Pick: Over 221.5 (computer predicts 223.5 points)
- Pick ATS: Timberwolves (-4.5)
Recent Timberwolves vs. Trail Blazers Matchups
| Date | Favorite | Spread | Total | Favorite Moneyline | Underdog Moneyline | Result |
|---|---|---|---|---|---|---|
| 2/8/2025 | Timberwolves | -3.5 | 212.5 | -163 | +137 | 114-98 MIN |
| 11/13/2024 | Timberwolves | -10 | 220 | -510 | +383 | 106-98 POR |
| 11/12/2024 | Timberwolves | -9.5 | 221.5 | -424 | +326 | 122-108 POR |
| 11/8/2024 | Timberwolves | -12 | 219.5 | -735 | +513 | 127-102 MIN |
Timberwolves 2024-25 Betting Trends
- Minnesota covered the spread 39 times in 82 games last year.
- As 4.5-point favorites or greater, the Timberwolves went 19-22 against the spread last year.
- Of Minnesota's 82 games last season, 44 went over the total.
- The Timberwolves were the moneyline favorite 63 total times last season. They went 40-23 in those games.
- When playing as a moneyline favorite with odds of -195 or shorter last year, Minnesota finished with a record of 26-11 (70.3%).
Trail Blazers 2024-25 Betting Trends
- Portland put together a 46-36-0 record against the spread last year.
- The Trail Blazers had an ATS record of 29-24 as underdogs of 4.5 points or more last year.
- A total of 40 of Portland's games last year went over the point total.
- Last season, the Trail Blazers won 26 out of the 69 games, or 37.7%, in which they were the underdog.
- Last season, Portland won 15 of its 49 games, or 30.6%, when it was the underdog by at least +163 on the moneyline.
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Timberwolves vs. Trail Blazers Injury Report
Timberwolves
Timberwolves: None
Trail Blazers
Trail Blazers:
Scoot Henderson: Out (Hamstring),
Damian Lillard: Out For Season (Achilles),
Robert Williams III: Out (Reconditioning)
Timberwolves vs. Trail Blazers Game Time and TV Channel
- Game day: Wednesday, October 22, 2025
- Game time: 10 p.m. ET
- TV channel: KUNP and FDSN
- Location: Portland, Oregon
- Arena: Moda Center
- Live stream: Watch this game on Fubo (Regional restrictions may apply)
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