Chiefs vs. Bills Week 9 Predictions, Odds and Stats

Washington Commanders v Kansas City Chiefs - NFL 2025

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Which team is going to win on Sunday, Nov. 2, when the Kansas City Chiefs and Buffalo Bills match up at 4:25 p.m. ET? Our projection model believes in the Chiefs. See our other projections below, where we break down the final score, spread, and over/under.

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Chiefs vs. Bills Game Info and TV Channel

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Chiefs vs. Bills Odds and Betting Info

  • Spread favorite: Chiefs (-2)
  • Moneyline: Chiefs (-134), Bills (+113)
  • Total: 53 points

Chiefs vs. Bills Prediction

  • Pick ATS: Chiefs (-2)
  • Pick OU: Under (53)

Prediction:

Chiefs 25 - Bills 22

    Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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    Chiefs vs. Bills Betting Insights

    • The Chiefs have compiled a 5-3-0 record against the spread this season.
    • The Bills are 3-4-0 ATS this season.
    • Kansas City has covered the spread four times this season (4-2 ATS) when playing as at least 2-point favorites.
    • Buffalo has been an underdog by 2 points or more this year twice, and failed to cover both times.
    • Chiefs games have hit the over three out of eight times this season.
    • In 2025, four Bills games have gone over the point total.

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