The Iowa State Cyclones (6-4) host a Big 12 clash against the Kansas Jayhawks (5-5) on Saturday, November 22, 2025 at Jack Trice Stadium.

Watch college football live without cable. Stream ACC, SEC, ESPN and more with Fubo. What is Fubo? Fubo is a streaming service that gives you access to your favorite live sports and shows on demand. Sign up today and start watching college football games now.

Iowa State vs. Kansas Matchup Info

Game date: Saturday, November 22, 2025
Game time: 12 p.m. ET
Location: Ames, Iowa
Venue: Jack Trice Stadium
TV channel: Fox Sports 1
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Stop missing games and start streaming college football right now on Fubo.

Iowa State vs. Kansas Odds and Prediction

Spread favorite: Cyclones (-3.5)
Moneyline: Cyclones (-179), Jayhawks (+149)
Total: 55.5 points
Pick ATS: Iowa State (-3.5)
Pick OU: Under (55.5)
Prediction: Iowa State 30, Kansas 21

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

Looking for officially licensed gear? Fanatics has jerseys, hats, apparel, memorabilia, trading cards, collectibles and more.

Iowa State vs. Kansas Betting Records and Insights

Iowa State is 4-5-1 ATS this season.
Kansas has put together a 4-6-0 ATS record so far this season.
The Cyclones have covered the spread twice when favored by 3.5 points or more this season (in four opportunities).
The Jayhawks have covered the spread once this year (1-2 ATS) when playing as at least 3.5-point underdogs.
So far this season, four of Iowa State's 10 games have gone over the point total.
In 2025, five Kansas games have hit the over.

The Drive with Heather and Lucas