The Iowa State Cyclones (6-4) and the Kansas Jayhawks (5-5) play on Saturday, November 22, 2025 at Jack Trice Stadium in a battle of Big 12 foes.

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Iowa State vs. Kansas Matchup Info

Game date: Saturday, November 22, 2025
Game time: 12 p.m. ET
Location: Ames, Iowa
Venue: Jack Trice Stadium
TV channel: Fox Sports 1
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Iowa State vs. Kansas Odds and Prediction

Spread favorite: Cyclones (-3.5)
Moneyline: Cyclones (-174), Jayhawks (+146)
Total: 55.5 points
Pick ATS: Iowa State (-3.5)
Pick OU: Under (55.5)
Prediction: Iowa State 30, Kansas 21

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Iowa State vs. Kansas Betting Records and Insights

Iowa State has won four games against the spread this season, while failing to cover or pushing six times.
Kansas has put together a 4-6-0 ATS record so far this season.
The Cyclones have covered the spread twice this season (2-2 ATS) when playing as at least 3.5-point favorites.
The Jayhawks have covered the spread once when an underdog by 3.5 points or more this year (in three opportunities).
So far this season, four of Iowa State's 10 games have gone over the point total.
So far this season, five of Kansas' 10 games with a set number have gone over the point total.

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