Big 12 foes match up when the Iowa State Cyclones (6-4) and the Kansas Jayhawks (5-5) square off on Saturday, November 22, 2025 at Jack Trice Stadium.

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Iowa State vs. Kansas Matchup Info

Game date: Saturday, November 22, 2025
Game time: 12 p.m. ET
Location: Ames, Iowa
Venue: Jack Trice Stadium
TV channel: Fox Sports 1
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Iowa State vs. Kansas Odds and Prediction

Spread favorite: Cyclones (-3.5)
Moneyline: Cyclones (-174), Jayhawks (+146)
Total: 55.5 points
Pick ATS: Iowa State (-3.5)
Pick OU: Under (55.5)
Prediction: Iowa State 30, Kansas 21

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Iowa State vs. Kansas Betting Records and Insights

Iowa State has put together a 4-5-1 record against the spread this season.
Kansas has put together a 4-6-0 record against the spread this season.
The Cyclones have covered the spread twice when favored by 3.5 points or more this season (in four opportunities).
The Jayhawks have covered the spread once when an underdog by 3.5 points or more this year (in three opportunities).
In Iowa State's 10 games this season, the combined scoring has gone over the point total four times.
Kansas games have hit the over five out of 10 times this year.

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