The Iowa Hawkeyes (6-4) play a conference opponent when they host the Michigan State Spartans (3-7) on Saturday, November 22, 2025 at Kinnick Stadium in a Big Ten clash.

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Iowa vs. Michigan State Matchup Info

Game date: Saturday, November 22, 2025
Game time: 3:30 p.m. ET
Location: Iowa City, Iowa
Venue: Kinnick Stadium
TV channel: Fox Sports 1
Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Iowa vs. Michigan State Odds and Prediction

Spread favorite: Hawkeyes (-16.5)
Moneyline: Hawkeyes (-935), Spartans (+613)
Total: 42.5 points
Pick ATS: Iowa (-16.5)
Pick OU: Over (42.5)
Prediction: Iowa 35, Michigan State 13

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Iowa vs. Michigan State Betting Records and Insights

Iowa is 7-2-1 ATS this season.
Michigan State has put together a 5-5-0 ATS record so far this year.
The Hawkeyes have been favored by 16.5 points or more two times this season, and covered the spread in one of those contests.
The Spartans have been an underdog by 16.5 points or more two times this year, and covered the spread both times.
So far this season, four of Iowa's 10 games have gone over the point total.
So far this season, six of Michigan State's 10 games with a set number have gone over the point total.

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